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Published research and studies help us communicate the efficacy and safety of our products. Please check back often as we will be adding studies as they are published.

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Antibacterial compounds from Glycyrrhiza uralensis
From the Journal of Natural Products

Glycyrrhiza uralensis, widely recognized as Chinese licorice, has been used in traditional medicine and naturopathy for thousands of years. In this study, several compounds isolated from G. uralensis were tested against Streptococcus mutans, a bacteria largely responsible for tooth decay. The study found that Glycyrrhizol A showed antibacterial properties against S. mutans, while Glycyrrihol B and isoflavanoid gancaonin G also showed moderate antibacterial results.

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Development and evaluation of a safe and effective
sugar-free herbal lollipop that kills cavity-causing bacteria
From the International Journal of Oral Science

In this study, the specific herbal extracts (Cavibloc) were used to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans (Loloz). Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested.

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Can a Licorice Lollipop Decrease Cariogenic Bacteria in Nursing Home Residents?

This population is particularly vulnerable to dental caries due to physical and mental limitations. Eight senior citizens were given at least one lollipop with licorice root extract per day for 21 days. Saliva samples were taken periodically throughout the study. In the end, the participants who consumed the lollipops more consistently had lower levels of Streptococcus mutans than the participants who
occasionally missed a day. Those who consistently consumed two per day had even lower levels of S.
mutans bacteria.

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Effects of herbal lollipops on Streptococcus Mutans levels, Lactobacilli levels and the dental caries experience of children with asthma taking beta2‐adrenergic drugs

The objective of this study was to determine how effective the six‐month regimen of herbal lollipops is at controlling the Streptococcus Mutans levels, Lactobacilli levels, and the caries process in the study group. This study showed evidence that the herbal lollipops decrease bacterial levels in the oral cavity. A decrease in bacteria, aids in decreasing the caries process, which most children using a beta2-°©-adrenergic agonist would benefit from. 

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Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study


Pre-schoolers aged 2-5 years were given a lollipop with an active ingredient of Glycyrrhiza uralensis each morning and afternoon for three weeks. Of the 66 students who participated fully in the study, 12 were low-risk for future caries risk, 37 were moderate-risk and 17 were high-risk. The study found that high-risk children had a significantly reduced population of Streptococcus mutans, that continued for 22 days after the three-week course of lollipops were administered.
 

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Effectiveness of a Novel Delivery System on Salivary Flow Rate, Quality of Life, and Inhibition of Caries Microbiota in Sjögren's Syndrome Patients

Sjögren's Syndrome is an auto immune disease, marked by an occurrence of dry mouth and lack of saliva production. Patients with Sjögren's Syndrome were recruited, and instructed to consume two lollipops a day. Some contained xylitol, some contained licorice root extract, and some contained an artificial sweetener. The study has so far found that patients who used the lollipops increased saliva production even after the 10-day course, and some patients showed a lowered bacterial count. 

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