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Published, peer-reviewed research and studies help us communicate the efficacy and safety of our products.
Check back often, as we will be adding studies as they are published.
Antibacterial compounds from Glycyrrhiza uralensis

Antibacterial compounds from Glycyrrhiza uralensis

From the Journal of Natural Products

Glycyrrhiza uralensis, widely recognized as Chinese licorice, has been used in traditional medicine and naturopathy for thousands of years. In this study, several compounds isolated from G. uralensis were tested against Streptococcus mutans, a bacteria largely responsible for tooth decay. The study found that Glycyrrhizol A showed antibacterial properties against S. mutans, while Glycyrrhizol B and isoflavanoid gancaonin G also showed moderate antibacterial results.

Can a Licorice Lollipop Decrease Cariogenic Bacteria in Nursing Home Residents?

This population is particularly vulnerable to dental caries due to physical and mental limitations. Eight senior citizens were given at least one lollipop with licorice root extract per day for 21 days. Saliva samples were taken periodically throughout the study. In the end, the participants who consumed the lollipops more consistently had lower levels of Streptococcus mutans than the participants who occasionally missed a day. Those who consistently consumed two per day had even lower levels of S. 
mutans bacteria.

Clinical reduction of S. mutans in pre-school children using a novel liquorice root extract lollipop: a pilot study

Pre-schoolers aged 2-5 years were given a lollipop with an active ingredient of Glycyrrhiza uralensis each morning and afternoon for three weeks. Of the 66 students who participated fully in the study, 12 were low-risk for future caries risk, 37 were moderate-risk and 17 were high-risk. The study found that high-risk children had a significantly reduced population of Streptococcus mutans, that continued for 22 days after the three-week course of lollipops were administered.
Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria

Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria

From the International Journal of Oral Science

In this study, the specific herbal extracts (Cavibloc) were used to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested.

Effects of herbal lollipops on Streptococcus Mutans levels, Lactobacilli levels and the dental caries experience of children with asthma taking beta2‐adrenergic drugs

The objective of this study was to determine how effective the six‐month regimen of herbal lollipops is at controlling the Streptococcus Mutans levels, Lactobacilli levels, and the caries process in the study group. This study showed evidence that the herbal lollipops decrease bacterial levels in the oral cavity. A decrease in bacteria, aids in decreasing the caries process, which most children using a beta2-°©-adrenergic agonist would benefit from.

Effectiveness of a Novel Delivery System on Salivary Flow Rate, Quality of Life, and Inhibition of Caries Microbiota in Sjögren's Syndrome Patients

Sjögren's Syndrome is an auto immune disease, marked by an occurrence of dry mouth and lack of saliva production. Patients with Sjögren's Syndrome were recruited, and instructed to consume two lollipops a day. Some contained xylitol, some contained licorice root extract, and some contained an artificial sweetener. The study has so far found that patients who used the lollipops increased saliva production even after the 10-day course, and some patients showed a lowered bacterial count.

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Without Cavibloc
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With Cavibloc

Cavibloc. See it in action!

These images were taken during a study at Oregon Health and Science University. Both plates contained S. mutan bacterial culture and underwent a 2-day incubation period. The image on the left is the control the image on the right contains Cavibloc. 

As you can see from these images, no growth was detectable on the THYE agar plates supplemented with Cavibloc extract. The Cavibloc-supplemented plates show that the extract completely inhibited S.
mutans growth, rather than simply slowing its growth through partial inhibition.

* Study was conducted with S. mutan bacterial culture UA159 (a caries isolate) plated onto both unsupplemented and Cavibloc-supplemented THYE agar plates. The plates were incubated anaerobically for 48 hr at 37 Celsius. After the incubation period, the plates were photographed.

Loloz in the news

Using candy to fight cavities

Stumptown Startups. Our first major piece of public relations. 

A cavity-fighting candy made with an extract from a specific compound found in licorice root. Satisfy your sweet tooth and fight cavities at the same time. Genius!
Portland Business Journal

Portland Business Journal

Moda Health banks on an inventive way to lick cavities
Eat This!

Eat This!

Uncovering a candy that wards off cavities and mindless munching
APEX 360

APEX 360

There's a new beneficial treat in town and it doesn't contain xylitol.
Portland Business Journal

Portland Business Journal

Pearls for your Practice is a syndicated dental product review column for dentists written by Joshua Austin, DDS, FAGD.
Dental Town

Dental Town

Helping patients maintain their oral health is always a top concern for most dentists...
Emerald City Journal

Emerald City Journal

A new product might be a natural alternative to costly cavities and gum disease.
Portland Business Journal

Portland Business Journal

Candy that really fights cavities.
DrBicuspid

DrBicuspid

Healthy Grid introduces caries-fighting lollipops.
Just Plum Crazy

Just Plum Crazy

Candy that fights cavities | Loloz anti cavity lollipops and lozenges.
Munchies!

Munchies!

This Gloriously Ironic Candy Actually Prevents Cavities
MomStart

MomStart

Can a Lollipop Fight Cavities?
Food & Wine

Food & Wine

New Candy Claims It Actually Prevents Cavities (Your Inner Child Can Thank Us Later)

With or without a stick?

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From the Loloz Blog

DECEMBER 27, 2018

PH and Oral Health: Why it Matters

What ingredient found in many foods and drinks is bad news for your teeth? The first thing that comes to your mind is probably sugar. While this is true, sometimes we forget another, equally damaging culprit: acid.

SEPTEMBER 28, 2018

Another Reason to Enjoy That Lollipop!

By now, most people are aware of the many "anti-cavity" candies out there, and how they can satiate a sweet tooth without compromising dental health. You may already be familiar with our product Loloz, which is a cavity, bad breath, and...
Don't take our word for it, try Loloz for yourself!